Ritonavir or lopinavir/ritonavir significantly enhance plasma concentrations of oxycodone in wholesome human volunteers as a consequence of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin significantly lowers plasma concentrations of oxycodone on account of strong induction of CYP3A4.A vital Portion of the assessment of the individual with Persiste

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